Topological analysis of GtrA and GtrB proteins encoded by the serotype-converting cassette of Shigella flexneri
Serotype conversion (O-antigen glucosylation) in Shigella flexneri is mediated by temperate bacteriophages, which encode a three-gene cluster that contains gtrA, gtrB, and gtr[type]. Sequence analysis has revealed that gtrA and gtrB are conserved and readily interchangeable between serotypes. The gtr[type] is unique in each serotype and responsible for specifically mediating conversion by the addition of a glucosyl group to the O-antigen units. Analysis of the GtrA and GtrB amino acid sequence...[Show more]
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