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Apocynin but not allopurinol prevents and reverses ACTH-induced hypertension in the rat

Zhang, Yi; Chan, Matthew; Andrews, Miles; Mori, Trevor A; Croft, Kevin D; McKenzie, Katja; Schyvens, Chris; Whitworth, Judith


Background: Adrenocorticotropic hormone (ACTH)-induced hypertension in the rat is accompanied by increased oxidative stress. This study examines the enzymatic source of reactive oxygen species in ACTH-hypertension. Methods: Male Sprague-Dawley rats were divided into 10 groups of 10-20 rats per group. The NAD(P)H oxidase inhibitor apocynin (1.5 mmol/L in drinking water) or the xanthine oxidase inhibitor allopurinol (200 mg/kg/day via food) were administered daily. After 4 days, rats were...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: American Journal of Hypertension
DOI: 10.1016/j.amjhyper.2005.02.017


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