Apocynin but not allopurinol prevents and reverses ACTH-induced hypertension in the rat
Background: Adrenocorticotropic hormone (ACTH)-induced hypertension in the rat is accompanied by increased oxidative stress. This study examines the enzymatic source of reactive oxygen species in ACTH-hypertension. Methods: Male Sprague-Dawley rats were divided into 10 groups of 10-20 rats per group. The NAD(P)H oxidase inhibitor apocynin (1.5 mmol/L in drinking water) or the xanthine oxidase inhibitor allopurinol (200 mg/kg/day via food) were administered daily. After 4 days, rats were...[Show more]
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|Source:||American Journal of Hypertension|
|01_Zhang_Apocynin_but_not_allopurinol_2005.pdf||246.88 kB||Adobe PDF||Request a copy|
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