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RNAi-based discovery and validation of new drug targets in filarial nematodes

Behm, Carolyn; Bendig, Mary; McCarter, James; Sluder, Ann

Description

Human filarial nematodes cause river blindness and lymphatic filariasis, both of which are diseases that produce considerable morbidity. Control of these diseases relies on drug treatments that are ineffective against macrofilariae and are threatened by the development of resistance. New validated drug targets are required to allow development of new classes of antifilarial drugs. To identify and validate potential new drug targets, we propose a collaborative research strategy utilizing...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/83158
Source: Trends in Parasitology
DOI: 10.1016/j.pt.2004.12.003

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