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Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex

Cullen, Karen M; Kocsi, Zoltan; Stone, Jonathan


In this post mortem study, we examined haem-rich deposits (HRDs) in patients with and without dementia, using a histochemical label (Prussian blue) to show haem, autofluorescence to detect red blood cells (RBCs), and immunohistochemistry for clotting-related factors and collagen IV. The patients studied had no clinical or post mortem evidence of macrovascular stroke. To allow examination of the spatial relationships between HRDs and the microvasculature, we cut 45-μm sections. Haem-rich...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Cerebral Blood Flow and Metabolism
DOI: 10.1038/sj.jcbfm.9600155


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