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High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malaria

Alleva, Lisa; Yang, H-C; Tracey, K; Clark, Ian A


High mobility group box 1 (HMGB1) protein, a DNA-binding protein that can also act as a pro-inflammatory cytokine if released from cells, is an important amplification signal in various forms of inflammation. The concentration of HMGB1 in serum taken at admission was increased in falciparum malaria in sixteen African children, more so in fatal cases than in those who subsequently recovered (P < 0.001). Serum from both non-fatal (P = 0.0048) and fatal (P < 0.001) cases contained significantly...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene
DOI: 10.1016/j.trstmh.2004.06.008


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