Alleva, Lisa; Yang, H-C; Tracey, K; Clark, Ian A
High mobility group box 1 (HMGB1) protein, a DNA-binding protein that can also act as a pro-inflammatory cytokine if released from cells, is an important amplification signal in various forms of inflammation. The concentration of HMGB1 in serum taken at admission was increased in falciparum malaria in sixteen African children, more so in fatal cases than in those who subsequently recovered (P < 0.001). Serum from both non-fatal (P = 0.0048) and fatal (P < 0.001) cases contained significantly...[Show more]
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