Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00 and 8:15 am on Tuesday, December 1 2020.

High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malaria

Alleva, Lisa; Yang, H-C; Tracey, K; Clark, Ian A


High mobility group box 1 (HMGB1) protein, a DNA-binding protein that can also act as a pro-inflammatory cytokine if released from cells, is an important amplification signal in various forms of inflammation. The concentration of HMGB1 in serum taken at admission was increased in falciparum malaria in sixteen African children, more so in fatal cases than in those who subsequently recovered (P < 0.001). Serum from both non-fatal (P = 0.0048) and fatal (P < 0.001) cases contained significantly...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene
DOI: 10.1016/j.trstmh.2004.06.008


File Description SizeFormat Image
01_Alleva_High_mobility_group_box_1_2005.pdf86.46 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator