Evaluation of radiolabelled peripheral benzodiazepine receptor ligand in the central nervous system inflammation of experimental autoimmune encephalomyelitis
Purpose: Peripheral benzodiazepine receptors (PBRs) are upregulated on macrophages and activated microglia, and radioligands for the PBRs can be used to detect in vivo neuroinflammatory changes in a variety of neurological insults, including multiple sclerosis. Substituted 2-phenyl imidazopyridine-3- acetamides with high affinity and selectivity for PBRs have been prepared that are suitable for radiolabelling with a number of positron emission tomography and single-photon emission computed...[Show more]
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|Source:||European Journal of Nuclear Medicine and Molecular Imaging|
|01_Mattner_Evaluation_of_radiolabelled_2004.pdf||304.92 kB||Adobe PDF||Request a copy|
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