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Evaluation of radiolabelled peripheral benzodiazepine receptor ligand in the central nervous system inflammation of experimental autoimmune encephalomyelitis

Mattner, F; Katsifis, Andrew; Staykova, Maria; Ballantyne, P; Willenborg, David


Purpose: Peripheral benzodiazepine receptors (PBRs) are upregulated on macrophages and activated microglia, and radioligands for the PBRs can be used to detect in vivo neuroinflammatory changes in a variety of neurological insults, including multiple sclerosis. Substituted 2-phenyl imidazopyridine-3- acetamides with high affinity and selectivity for PBRs have been prepared that are suitable for radiolabelling with a number of positron emission tomography and single-photon emission computed...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: European Journal of Nuclear Medicine and Molecular Imaging
DOI: 10.1007/s00259-004-1690-y


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