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Expression of rat I-TAC/CXCL11/SCYA11 during central nervous system inflammation: comparison with other CXCR3 ligands

McColl, Shaun; Mahalingam, Suresh (Surendran); Staykova, Maria; Tylaska, Laurie; Fisher, Katherine E; Strick, Christine; Gladue, Ronald; Willenborg, David; Neote, Kuldeep

Description

The chemokines are a large gene superfamily with critical roles in development and immunity. The chemokine receptor CXCR3 appears to play a major role in the trafficking of activated Th1 lymphocytes. There are at least three major ligands for CXCR3: mig/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11, and of these three ligands, CXCL11 is the least well-characterized. In this study, we have cloned a rat ortholog of CXCL11, evaluated its function, and examined its expression in the Th-1-mediated disease,...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/82952
Source: Laboratory Investigation
DOI: 10.1038/labinvest.3700155

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