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Differentiation of the follicle-associated epithelium in ileal Peyers patch and production of 50-nm particles are maintained in B-cell-depleted fetal sheep

Lie, K-I; Press, C M; McCullagh, Peter; McClure, Susan J; Landsverk, T


To evaluate the dependence of the differentiation of the follicle-associated epithelium (FAE) on the presence of follicular B-cells, the FAE of ileal Peyer's patch follicles was examined in B-cell-depleted fetal lambs. The FAE of these rudimentary follicles, which are devoid of lymphocytes, showed normal differentiation, including carbonic anhydrase reactivity and ultrastructural characteristics of transcytosis, extensive interdigitation of the lateral plasma membrane and the shedding of...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Cell and Tissue Research
DOI: 10.1007/s00441-004-0977-4


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