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Development of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B core antigen to stimulate a strong Th1 response against hepatitis B surface antigen

Aguilar, J C; Lobaina, Y; Muzio, V; Garcia, D; Penton, E; Iglesias, E; Pichardo, D; Urquiza, D; Rodriguez, D; Silva, Diego; Petrovsky, Nikolai; Guillen, G


There are estimated to be 350 million chronic carriers of hepatitis B infection worldwide. Patients with chronic hepatitis B are at risk of liver cirrhosis with associated mortality because of hepatocellular carcinoma and other complications. An important goal, therefore, is the development of an effective therapeutic vaccine against chronic hepatitis B virus (HBV). A major barrier to the development of such a vaccine is the impaired immune response to HBV antigens observed in the T cells of...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1111/j.0818-9641.2004.01278.x


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