Whole-Cell Biotransformation of m -Ethyltoluene into 1 S ,6 R -5-Ethyl-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylic Acid as an Approach to the C-Ring of the Binary Indole�Indoline Alkaloid Vinblastine.
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Banwell, Martin; Edwards, Alison; Lupton, David; Whited, Gregg
Description
The title compound 3, a potential building block for the construction of analogues of the clinically important anticancer agent vinblastine (1), has been prepared in an efficient manner through a whole-cell biotransformation of m-ethyltoluene (4) using the microorganism Pseudomonas putida BGXM1 which expresses the enzyme toluate dioxygenase (TADO). Metabolite 3 was readily converted into derivatives 5-8 using conventional chemical techniques and the structure, including absolute...[Show more]
Collections | ANU Research Publications |
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Date published: | 2005 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/82787 |
Source: | Australian Journal of Chemistry |
DOI: | 10.1071/CH04185 |
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01_Banwell_Whole-Cell_Biotransformation_2005.pdf | 208.18 kB | Adobe PDF | Request a copy |
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