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A parametric assessment of GABA antagonist effects on paired-pulse facilitation in the rat anterior cingulate cortex

Sylantyev, Sergiy; Lee, Chia-Ming; Shyu, Bai-Chuang


Paired-pulse facilitation (PPF) is a form of short-term plasticity that can be used qualitatively to characterize the synaptic effects of neuroactive compounds. As we have shown previously, CNQX has a marked effect on PPF which can be measured quantitatively. The aim of the present study was to examine quantitatively possible differences in the effects of the post- and pre-synaptic GABA antagonists on PPF in vitro. Experiments were performed on slices taken from the coronal anterior cingulate...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Neuroscience Research
DOI: 10.1016/j.neures.2005.04.009


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