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Time Course of Neurotrophic Factor Upregulation and Retinal Protection against Light-Induced Damage after Optic Nerve Section

Valter (Valter-Kocsi), Krisztina; Bisti, Silvia; Gargini, Claudia; Di Loreto, Silvia; Maccarone, Rita; Cervetto, Luigi; Stone, Jonathan

Description

PURPOSE. To assess neurotrophic factor upregulation in the retina after damage to the optic nerve and relate that regulation to changes in photoreceptor stability and function. METHODS. Retinas of adult pigmented (Long-Evans) rats were examined at successive times (1-60 days) after unilateral optic nerve section. The distribution and expression of ciliary neurotrophic factor (CNTF) and basic flbroblast growth factor (FGF-2) and their receptor elements FGFR1 and CNTFRα were studied with...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/82410
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.04-0657

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