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Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival

Ferry, Helen; Cockford, Tanya L; Silver, Karlee; Rust, Nigel; Goodnow, Christopher; Cornall, Richard J


B cell fate is determined by the strength of signals from the antigen receptor and from co-receptors that adjust the activation threshold and tune the B cell to its environment. These co-receptors have been broadly classified into inhibitory and enhancing groups, yet some, such as CD22, may have dual effects. CD22 recruits a variety of signal enhancers at the same time as Lyn-dependent phosphorylation leads to the binding of the inhibitory phosphatase SHP-1. To assess the relative importance of...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: European Journal of Immunology
DOI: 10.1002/eji.200535247


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