Skip navigation
Skip navigation

Reduced memory B cells in patients with hyper IgE syndrome

Speckmann, Carsten; Enders, Anselm; Woellner, C.; Thiel, D.; Rensing-Ehl, A.; Schlesier, Michael; Rohr, Jan; Jakob, T.; Oswald, E.; Kopp, Matthias; Sanal, O.; Litzman, J.; Plebani, A.; Pietrogrande, M.C.; Franco, J.L.; Espanol, T.; Grimbacher, B.; Ehl, Stephan


Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Clinical Immunology
DOI: 10.1016/j.clim.2008.08.002


File Description SizeFormat Image
01_Speckmann_Reduced_memory_B_cells_in_2008.pdf303.15 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator