Reduced memory B cells in patients with hyper IgE syndrome
Speckmann, Carsten; Enders, Anselm; Woellner, C.; Thiel, D.; Rensing-Ehl, A.; Schlesier, Michael; Rohr, Jan; Jakob, T.; Oswald, E.; Kopp, Matthias; Sanal, O.; Litzman, J.; Plebani, A.; Pietrogrande, M.C.; Franco, J.L.; Espanol, T.; Grimbacher, B.; Ehl, Stephan
Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels...[Show more]
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