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Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections

Potter, S M; Mitchell, A J; Cowden, William; Sanni, L A; Dinauer, M; de Haan, J B; Hunt, N H


Phagocyte-derived reactive oxygen species have been implicated in the clearance of malaria infections. We investigated the progression of five different strains of murine malaria in gp91phox-/- mice, which lack a functional NADPH oxidase and thus the ability to produce phagocyte-derived reactive oxygen species. We found that the absence of functional NADPH oxidase in the gene knockout mice had no effect on the parasitemia or total parasite burden in mice infected with either resolving...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Infection and Immunity
DOI: 10.1128/IAI.73.8.4941-4947.2005


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