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Phosphorylation of skeletal muscle calsequestrin enhances its Ca2+ binding capacity and promotes its association with junctin

Beard, Nicole; Wei, Lan; Cheung, Stephanie; Kimura, Takashi; Varsanyi, Magdolna; Dulhunty, Angela


Calcium signaling, intrinsic to skeletal and cardiac muscle function, is critically dependent on the amount of calcium stored within the sarcoplasmic reticulum. Calsequestrin, the main calcium buffer in the sarcoplasmic reticulum, provides a pool of calcium for release through the ryanodine receptor and acts as a luminal calcium sensor for the channel via its interactions with triadin and junctin. We examined the influence of phosphorylation of calsequestrin on its ability to store calcium, to...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Cell Calcium
DOI: 10.1016/j.ceca.2008.01.005


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