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Natural selection shapes genome-wide patterns of copy-number polymorphism in Drosophila melanogaster

Emerson, J J; Cardoso-Moreira, Margarida M.; Borevitz, Justin; Long, Manyuan


The role that natural selection plays in governing the locations and early evolution of copy-number mutations remains largely unexplored. We used high-density full-genome tiling arrays to create a fine-scale genomic map of copy-number polymorphisms (CNPs) in Drosophila melanogaster. We inferred a total of 2658 independent CNPs, 56% of which overlap genes. These include CNPs that are likely to be under positive selection, most notably high-frequency duplications encompassing toxin-response...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Science
DOI: 10.1126/science.1158078


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