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Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster

Zavortink, Michael; Contreras, Nelida; Addy, Tracie; Bejsovec, Amy; Saint, Robert


A central question in understanding cytokinesis is how the cleavage plane is positioned. Although the positioning signal is likely to be transmitted via the anaphase microtubule array to the cell cortex, exactly how the microtubule array determines the site of contractile ring formation remains unresolved. By analysing tum/RacGAP50C mutant Drosophila embryos we show that cells lacking Tum do not form furrows and fail to localise the key cytokinetic components Pebble (a RhoGEF), Aurora B kinase,...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Cell Science
DOI: 10.1242/jcs.02652


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