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The F1-ATP synthase complex in bloodstream stage typanosomes has an unusual and essential function

Schnaufer, Achim; Clark-Walker, George; Steinberg, Alodie; Stuart, Ken

Description

Survival of bloodstream form Trypanosoma brucei, the agent of African sleeping sickness, normally requires mitochondrial gene expression, despite the absence of oxidative phosphorylation in this stage of the parasite's life cycle. Here we report that silencing expression of the α subunit of the mitochondrial F1-ATP synthase complex is lethal for bloodstream stage T. brucei as well as for T. evansi, a closely related species that lacks mitochondrial protein coding genes (i.e. is...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/82056
Source: EMBO Journal, The
DOI: 10.1038/sj.emboj.7600862

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