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Interferon function is not required for recovery from a secondary poxvirus infection

Panchanathan, Vijay; Chaudhri, Geeta; Karupiah, Gunasegaran


IFN function is critical for recovery from most primary viral infections, including poxvirus infection. In contrast, very little is known about the requirement for IFN function in mediating recovery from a secondary virus infection. We have used ectromelia virus (EOV), an orthopoxvirus very closely related to variola virus, to investigate the importance of IFN function in recovery from a secondary infection. Variola virus, the causative agent of smallpox in humans, and ECTV, which causes...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0505180102


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