Functional analysis of granzyme M and its role in immunity to infection
Pao, Lily I; Sumaria, Nital; Kelly, Janice M; van Dommelen, Serani; Cretney, Erika; Wallace, Morgan E; Anthony, Desiree A; Uldrich, Adam P; Godfrey, Dale I; Papadimitriou, John M; Mullbacher, Arno; Degli-Esposti, Mariapia A; Smyth, Mark J
Cytotoxic lymphocytes express a large family of granule serine proteases, including one member, granzyme (Grz)M, with a unique protease activity, restricted expression, and distinct gene locus. Although a number of Grzs, including GrzM, have been shown to mediate target cell apoptosis in the presence of perforin, the biological activity of Grz has been restricted to control of a number of viral pathogens, including two natural mouse pathogens, ectromelia, and murine CMV (MCMV). In this article,...[Show more]
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