Skip navigation
Skip navigation

Functional analysis of granzyme M and its role in immunity to infection

Pao, Lily I; Sumaria, Nital; Kelly, Janice M; van Dommelen, Serani; Cretney, Erika; Wallace, Morgan E; Anthony, Desiree A; Uldrich, Adam P; Godfrey, Dale I; Papadimitriou, John M; Mullbacher, Arno; Degli-Esposti, Mariapia A; Smyth, Mark J

Description

Cytotoxic lymphocytes express a large family of granule serine proteases, including one member, granzyme (Grz)M, with a unique protease activity, restricted expression, and distinct gene locus. Although a number of Grzs, including GrzM, have been shown to mediate target cell apoptosis in the presence of perforin, the biological activity of Grz has been restricted to control of a number of viral pathogens, including two natural mouse pathogens, ectromelia, and murine CMV (MCMV). In this article,...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/81959
Source: Journal of Immunology

Download

File Description SizeFormat Image
01_Pao_Functional_analysis_of_2005.pdf1.02 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator