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Comparison of whole gene and whole virus scrambled antigen approaches for DNA prime and fowlpox virus boost HIV type 1 vaccine regimens in macaques

Pamungkas, Joko; De Rose, Robert; Iskandriati, Diah; Noviana, Rachmitasari; Paramastri, Yasmina; Dale, C Jane; Shoobridge, Maryanne; Medveczky, C; Ramshaw, Ian; Thomson, Scott; Kent, Stephen J

Description

T cell immunity plays a critical role in controlling HIV-1 viremia, and encoding a limited set of HIV-1 genes within DNA and poxvirus vectors can, when used sequentially, induce high levels of T cell immunity in primates. However, a limited breadth of T cell immunity exposes the host to potential infection with either genetically diverse HIV-1 strains or T cell escape variants of HIV-1. In an attempt to induce maximally broad immunity, we examined DNA and recombinant fowlpox virus (rFPV)...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/81934
Source: AIDS Research and Human Retroviruses
DOI: 10.1089/aid.2005.21.292

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