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Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase

Kim, Hye-Kyung; Liu, Jian-Wei; Carr, Paul D; Ollis, David

Description

The enzyme dienelactone hydrolase (DLH) has undergone directed evolution to produce a series of mutant proteins that have enhanced activity towards the non-physiological substrates α-naphthyl acetate and p-nitrophenyl acetate. In terms of steady-state ki

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/81927
Source: Acta Crystallographica Section D: Biological Crystallography
DOI: 10.1107/S0907444905009042

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