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Cellular and genetic mechanisms of self tolerance and autoimmunity

Goodnow, Christopher; Sprent, Jonathon; Fazekas de St Groth, Barbara; Garcia De Vinuesa, Maria Carola


The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body. Inevitably, some of these receptors recognize components of our own body, and so cellular mechanisms have evolved to control the activity of these 'forbidden' receptors and achieve immunological self tolerance. Many of the genes and proteins involved are conserved between humans and other mammals. This provides the bridge between clinical studies and...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Nature
DOI: 10.1038/nature03724


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