A randomized controlled trial of Cyclosporine withdrawal in renal-transplant recipients: 15-year results
Background. In renal transplantation, the immunosuppressive efficacy of cyclosporine is counterbalanced by its nephrotoxicity. Although cyclosporine improves short-term graft survival, its long-term effects are unclear. Methods. Recipients of first cadaver renal transplants were randomized into three groups between 1983 and 1986: azathioprine and prednisolone alone (AP, n= 158), long term cyclosporine alone (Cy, n= 166), and short-term cyclosporine followed by azathioprine and prednisolone...[Show more]
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