Divergent mechanisms of suicide inactivation for ethanolamine ammonia-lyase
Ab initio molecular orbital calculations have been used to study the mechanism of suicide inactivation of ethanolamine ammonia-lyase induced by three different substrate analogues. Analysis of the normal catalytic mechanism with 2-aminoethanol (ethanolamine) as substrate predicts that both the hydrogen-abstraction and hydrogen-reabstraction steps involving the B 12-cofactor are likely to be exothermic. On the other hand, the proposed inactivation mechanism for the first substrate analogue,...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of the American Chemical Society|
|01_Sandala_Divergent_mechanisms_of_2005.pdf||121.16 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.