Skip navigation
Skip navigation

Divergent mechanisms of suicide inactivation for ethanolamine ammonia-lyase

Sandala, Gregory; Smith, David M; Radom, Leo

Description

Ab initio molecular orbital calculations have been used to study the mechanism of suicide inactivation of ethanolamine ammonia-lyase induced by three different substrate analogues. Analysis of the normal catalytic mechanism with 2-aminoethanol (ethanolamine) as substrate predicts that both the hydrogen-abstraction and hydrogen-reabstraction steps involving the B 12-cofactor are likely to be exothermic. On the other hand, the proposed inactivation mechanism for the first substrate analogue,...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/81619
Source: Journal of the American Chemical Society
DOI: 10.1021/ja051527k

Download

File Description SizeFormat Image
01_Sandala_Divergent_mechanisms_of_2005.pdf121.16 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator