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A new type 1 diabetes susceptibitity locus containing the catalase gene (chromosome 11p13) in a Russian population

Chistiakov, D A; Savost'anov, K V; Turakulov, R; Titovich, E V; Zilberman, L I; Kuraeva, T L; Dedov, I I; Nosikov, V V


Background. Oxidative stress is involved in the origin of type 1 diabetes. Low efficiency of the scavenging antioxidant system has been shown to be related to the pathogenesis of the disease. This, therefore suggests that genes encoding catalase and other antioxidant enzymes may implicate in the development of type 1 diabetes. Methods. Nine microsatellite markers that cover about 10 megabases around the catalase (CAT) gene on chromosome 11p13 were analyzed using polymerase chain reaction (PCR)...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Diabetes-Metabolism research and reviews
DOI: 10.1002/dmrr.442


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