Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes
Hu, Liping; Deeney, Jude T; Nolan, Christopher; Peyot, Marie-Line; Ao, Ada; Richard, Ann Marie; Luc, Esthere; Faergeman, Nils J; Knudsen, Jens; Guo, Wen; Sorhede-Winzell, Maria; Prentki, Marc; Corkey, Barbara E
Intracellular lipolysis is a major pathway of lipid metabolism that has roles, not only in the provision of free fatty acids as energy substrate, but also in intracellular signal transduction. The latter is likely to be particularly important in the regulation of insulin secretion from islet β-cells. The mechanisms by which lipolysis is regulated in different tissues is, therefore, of considerable interest. Here, the effects of long-chain acyl-CoA esters (LC-CoA) on lipase activity in islets...[Show more]
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|Source:||American Journal of Physiology - Endocrinology and Metabolism|
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