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Complexity generation in fungal polyketide biosynthesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin

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Cacho, Ralph A; Chooi, Yit-Heng; Zhou, Hui; Tang, Yi

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Griseofulvin (1) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes. Formation of the spirocycle, or the grisan scaffold, from a benzophenone precursor is critical for the activity of 1. In this study, we have systematically

dc.contributor.authorCacho, Ralph A
dc.contributor.authorChooi, Yit-Heng
dc.contributor.authorZhou, Hui
dc.contributor.authorTang, Yi
dc.date.accessioned2015-12-13T22:52:22Z
dc.identifier.issn1554-8929
dc.identifier.urihttp://hdl.handle.net/1885/81536
dc.description.abstractGriseofulvin (1) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes. Formation of the spirocycle, or the grisan scaffold, from a benzophenone precursor is critical for the activity of 1. In this study, we have systematically
dc.publisherAmerican Chemical Society
dc.sourceACS chemical biology
dc.titleComplexity generation in fungal polyketide biosynthesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume8
dc.date.issued2013
local.identifier.absfor060107 - Enzymes
local.identifier.absfor030401 - Biologically Active Molecules
local.identifier.ariespublicationf5625xPUB9818
local.type.statusPublished Version
local.contributor.affiliationCacho, Ralph A , University of California,
local.contributor.affiliationChooi, Yit-Heng, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationZhou, Hui, University of California
local.contributor.affiliationTang, Yi, University of California
local.description.embargo2037-12-31
local.bibliographicCitation.issue10
local.bibliographicCitation.startpage2322
local.bibliographicCitation.lastpage2330
local.identifier.doi10.1021/cb400541z
local.identifier.absseo860903 - Veterinary Pharmaceutical Treatments (e.g. Antibiotics)
local.identifier.absseo860803 - Human Pharmaceutical Treatments (e.g. Antibiotics)
dc.date.updated2015-12-11T10:50:42Z
local.identifier.scopusID2-s2.0-84886495241
local.identifier.thomsonID000326121400027
CollectionsANU Research Publications

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