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Complexity generation in fungal polyketide biosynthesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin

Cacho, Ralph A; Chooi, Yit-Heng; Zhou, Hui; Tang, Yi


Griseofulvin (1) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes. Formation of the spirocycle, or the grisan scaffold, from a benzophenone precursor is critical for the activity of 1. In this study, we have systematically

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: ACS chemical biology
DOI: 10.1021/cb400541z


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