Skip navigation
Skip navigation

Complexity generation in fungal polyketide biosynthesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin

Cacho, Ralph A; Chooi, Yit-Heng; Zhou, Hui; Tang, Yi

Description

Griseofulvin (1) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes. Formation of the spirocycle, or the grisan scaffold, from a benzophenone precursor is critical for the activity of 1. In this study, we have systematically

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/81536
Source: ACS chemical biology
DOI: 10.1021/cb400541z

Download

File Description SizeFormat Image
01_Cacho_Complexity_generation_in_2013.pdf2.69 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator