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The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of -trans-bergamotene

Lin, Hsiao-Ching; Chooi, Yit-Heng; Dhingra, Sourabh; Xu, Wei; Calvo, Ana M; Tang, Yi

Description

Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability of

dc.contributor.authorLin, Hsiao-Ching
dc.contributor.authorChooi, Yit-Heng
dc.contributor.authorDhingra, Sourabh
dc.contributor.authorXu, Wei
dc.contributor.authorCalvo, Ana M
dc.contributor.authorTang, Yi
dc.date.accessioned2015-12-13T22:52:12Z
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/1885/81463
dc.description.abstractFumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability of
dc.publisherAmerican Chemical Society
dc.sourceJournal of the American Chemical Society
dc.subjectKeywords: Acyltransferase; Anti-angiogenic activity; Aspergillus fumigatus; Biosynthetic gene cluster; Genome sequences; Methionine aminopeptidase; Molecular basis; Polyketide synthases; Amino acids; Aspergillus; Biochemistry; Biosynthesis; Plants (botany); Terpene
dc.titleThe fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of -trans-bergamotene
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume135
dc.date.issued2013
local.identifier.absfor060705 - Plant Physiology
local.identifier.ariespublicationf5625xPUB9754
local.type.statusPublished Version
local.contributor.affiliationLin, Hsiao-Ching, University of California
local.contributor.affiliationChooi, Yit-Heng, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationDhingra, Sourabh, Northern Illinois University
local.contributor.affiliationXu, Wei, University of California
local.contributor.affiliationCalvo, Ana M, Northern Illinois University
local.contributor.affiliationTang, Yi, University of California
local.description.embargo2037-12-31
local.bibliographicCitation.issue12
local.bibliographicCitation.startpage4616
local.bibliographicCitation.lastpage4619
local.identifier.doi10.1021/ja312503y
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2016-02-24T09:46:18Z
local.identifier.scopusID2-s2.0-84875749007
local.identifier.thomsonID000317032000011
CollectionsANU Research Publications

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