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Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-1 in nerve terminals

Xue, Jing; Milburn, Peter J; Hanna, Bernadette; Graham, Mark E; Rostas, John A P; Robinson, Phillip J


The septins are a family of GTPase enzymes required for cytokinesis and play a role in exocytosis. Among the ten vertebrate septins, Sept5 (CDCrel-1) and Sept3 (G-septin) are primarily concentrated in the brain, wherein Sept3 is a substrate for PKG-I (cGMP-dependent protein kinase-I) in nerve terminals. There are two motifs for potential PKG-I phosphorylation in Sept3, Thr-55 and Ser-91, but phosphoamino acid analysis revealed that the primary site is a serine. Derivatization of phosphoserine...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Biochemical Journal
DOI: 10.1042/BJ20040455


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