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Kv channel S6 helix as a molecular switch: simulation studies

Bright, Joanne Nicole; Sansom, Mark S P


Ion channels form pores of nanoscopic dimensions in biological membranes and play a key role in the physiology of cells. The majority of ion channels are gated, i.e. they contain a molecular switch that allows a transition between a closed (functionally 'off') and open (functionally 'on') state. Comparison of crystal structures of potassium channels suggest that the gating mechanism of voltage-gated potassium (Kv) channels involves a key role for the pore-lining S6 helix. There is a conserved...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: IEE Proceedings - Nanobiotechnology
DOI: 10.1049/ip-nbt:20040101


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