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Differences in glycinergic mIPSCs in the auditory brain stem of normal and congenitally deaf neonatal mice

Leao, Richardson; Oleskevich, Sharon; Sun, Hong; Bautista, M; Fyffe, Robert E W; Walmsley, Bruce


We have investigated the fundamental properties of central auditory glycinergic synapses in early postnatal development in normal and congenitally deaf (dn/dn) mice. Glycinergic miniature inhibitory postsynaptic currents (mIPSCs) were recorded using patch-clamp methods in neurons from a brain slice preparation of the medial nucleus of the trapezoid body (MNTB), at 12-14 days postnatal age. Our results show a number of significant differences between normal and deaf mice. The frequency of mIPSCs...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Neurophysiology
DOI: 10.1152/jn.00771.2003


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