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Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery

Sandow, Shaun L; Goto, Kenichi; Rummery, Nicole; Hill, Caryl


A role for myoendothelial gap junctions (MEGJs) has been proposed in the action of the vasodilator endothelium-derived hyperpolarizing factor (EDHF). EDHF activity varies in disease and during ageing, but little is known of the role of EDHF during development when, in many organ systems, gap junctions are up-regulated. The aims of the present study were therefore to determine whether an up-regulation of heterocellular gap junctional coupling occurs during arterial development and whether this...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2003.058669


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