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Inositol 1,4,5-trisphosphate receptor subtypes are differentially distributed between smooth muscle and endothelial layers of rat arteries

Grayson, Thomas; Haddock, Rebecca; Murray, Tracy; Wojcikiewicz, Richard J H; Hill, Caryl


In blood vessels, the ability to control vascular tone depends on extracellular calcium entry and the release of calcium from inositol 1,4,5-trisphosphate receptor (IP3R)-gated stores located in both the endothelial and smooth muscle cells of the vascular wall. Therefore, we examined mRNA expression and protein distribution of IP3R subtypes in intact aorta, basilar and mesenteric arteries of the rat. IP3R1 mRNA was predominantly expressed in all three arteries. Immunohistochemistry showed that...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Cell Calcium
DOI: 10.1016/j.ceca.2004.04.005


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