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Association between chronic fatigue syndrome and the corticosteroid-binding globulingene ALA SER224 polymorphism

Torpy, David J; Bachmann, Anthony W; Gartside, M; Grice, Jeffrey E; Harris, J M; Clifton, P; Easteal, Simon; Jackson, Richard; Whitworth, Judith


Chronic fatigue syndrome (CFS) is characterized by idiopathic fatigue of greater than 6 months' duration with postexertional exacerbation and many other symptoms. A trend toward relative hypocortisolism is described in CFS. Twin and family studies indicate a substantial genetic etiologic component to CFS. Recently, severe corticosteroid-binding globulin (CBG) gene mutations have been associated with CFS in isolated kindreds. Human leukocyte elastase, an enzyme important in CBG catabolism at...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Endocrine Research
DOI: 10.1081/ERC-200035599


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