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TSPY, the cadidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X-implications for Y chromosome evolution

Delbridge, Margaret; Longepied, Guy; Depetris, Danielle; Mattei, Marle-Genevieve; Disteche, Christine M; Graves, Jennifer; Mitchell, Michael J

Description

TSPY, a candidate gene for a factor that promotes gonadoblastoma formation (GBY), is a testis-specific multicopy gene family in the male-specific region of the human Y (MSY) chromosome. Although it was originally proposed that male-specific genes on the Y originated from a transposed copy of an autosomal gene (Lahn & Page 1999b), at least two male-specific genes (RBMY and SRY) descended from a formerly recombining X-Y identical gene pair. Here we show that a TSPY homologue with similar gene...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/81072
Source: Chromosome Research
DOI: 10.1023/B:CHRO.0000034134.91243.1c

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