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Adrenocorticotropic Hormone, Blood Pressure, and Serum Erythropoietin Concentrations in the Rat

Zhang, Yi; Andrews, Miles; Schyvens, Chris; McKenzie, Katja; Whitworth, Judith


Background This study was designed to investigate the effects of adrenocorticotropic hormone (ACTH) on systolic blood pressure (BP) and serum erythropoietin (EPO) concentrations in two strains of rats. We hypothesized that ACTH-induced hypertension in the rat is characterized by increased EPO production. Methods Male Sprague-Dawley (SD) and Wistar out-bred (Wistar) rats were treated with saline or ACTH (0.2 mg/kg/d). Systolic BP was measured using the tail-cuff method. Serum EPO concentrations...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: American Journal of Hypertension
DOI: 10.1016/j.amjhyper.2004.01.004


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