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Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis

Schermer, Tjard R.J.; Chavannes, Niels; Dekhuijzen, Richard; Wouters, Emiel; Muris, Jean; Akkermans, Reinier; van Schayck, Onno; van Weel, Chris


Background: Increased oxidative stress and bronchial inflammation are important mechanisms in the pathophysiology of COPD. Aim: To investigate whether treatment with the inhaled corticosteroid fluticasone propionate (FP) or the anti-oxidative agent N-acetylcysteine (NAC) are effective in primary care patients. Methods: The study was a 3-year placebo-controlled randomised controlled trial preceded by a 3-month washout and 2-week prednisolone pre-treatment. Patients were (ex-)smokers with chronic...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Respiratory Medicine
DOI: 10.1016/j.rmed.2008.11.003


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