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Opioids inhibit lateral amygdala pyramidal neurons by enhancing a dendritic potassium current

Faber, Elizabeth (Louise); Sah, Pankaj

Description

Pyramidal neurons in the lateral amygdala discharge trains of action potentials that show marked spike frequency adaptation, which is primarily mediated by activation of a slow calcium-activated potassium current. We show here that these neurons also express an α-dendrotoxin- and tityustoxin-Kα-sensitive voltage-dependent potassium current that plays a key role in the control of spike discharge frequency. This current is selectively targeted to the primary apical dendrite of these neurons....[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/81063
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.4496-03.2004

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