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Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum -Infected Erythrocytes

Go, Mei-Lin; Liu, Mei; Wilairat, Prapon; Saliba, Kevin; Kirk, Kiaran

Description

A series of alkoxylated and hydroxylated chalcones previously reported to have antiplasmodial activities in vitro were investigated for their effects on the new permeation pathways induced by the malaria parasite in the host erythrocyte membrane. Of 21 compounds with good antiplasmodial activities (50% inhibitory concentrations [IC50s], ≤20 μM), 8 members were found to inhibit sorbitol-induced lysis of parasitized erythrocytes to a significant extent (≤40% of control values) at a concentration...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/81059
Source: Antimicrobial Agents and Chemotherapy
DOI: 10.1128/AAC.48.9.3241-3245.2004

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