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Substance P release in the cat spinal cord upon afferent C-fibre stimulation is not attenuated by clonidine at analgesic doses

Lacey, Michael; Hendry, Ian; Morton, Cecil Robert


In anaesthetized cats, antibody microprobes were used to measure the release of immunoreactive substance P (irSP) in the lumbar dorsal horn during electrical stimulation of primary afferent fibres at intensities suprathreshold for unmyelinated fibres. Release of irSP was detected in the region of the superficial dorsal horn. This evoked release was not reduced by clonidine hydrochloride, administered intravenously or by superfusion of the dorsal cord surface. Microprobes inserted during cord...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Neuroscience Letters
DOI: 10.1016/j.neulet.2003.12.070


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