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Deletion of guanine nucleotide binding protein alpha-Z subunit in mice induces a gene dose dependent tolerance to morphine

Leck, Kwong-Joo; Bartlett, Selena; Smith, M; Megirian, David; Holgate, Joan; Powell, Kim; Matthaei, Klaus; Hendry, Ian


The mechanism underlying the development of tolerance to morphine is still incompletely understood. Morphine binds to opioid receptors, which in turn activates downstream second messenger cascades through heterotrimeric guanine nucleotide binding proteins (G proteins). In this paper, we show that G z, a member of the inhibitory G protein family, plays an important role in mediating the analgesic and lethality effects of morphine after tolerance development. We blocked signaling through the Gz...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Neuropharmacology
DOI: 10.1016/j.neuropharm.2003.11.024


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