Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-Methyl-D-aspartate receptors

Abstract

ATP and glutamate are fast excitatory neurotransmitters in the central nervous system acting primarily on ionotropic P2X and glutamate [N-methyl-D-aspartate (NMDA) and non-NMDA] receptors, respectively. Both neurotransmitters regulate synaptic plasticity