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Role of Tetrahydrobiopterin in Adrenocorticotropic Hormone-Induced Hypertension in the Rat

Zhang, Yi; Earl, John; Schyvens, Chris; McKenzie, Katja; Whitworth, Judith

Description

Adrenocorticotropic hormone (ACTH)-induced hypertension in the rat is characterized by nitric oxide deficiency. Tetrahydrobiopterin (BH4) is an essential cofactor for the enzyme nitric oxide synthase and glucocorticoids have been reported to reduce cytokine-induced BH4 production. Accordingly we hypothesized that ACTH-induced hypertension would be reversed by BH4 supplementation. Male Sprague-Dawley rats (n = 33) were treated with BH4 in vehicle (10 mg/kg/day i.p.) or vehicle alone (5 mg/kg/day...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/81031
Source: Clinical and Experimental Hypertension
DOI: 10.1081/CEH-120030232

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