Role of Tetrahydrobiopterin in Adrenocorticotropic Hormone-Induced Hypertension in the Rat
Adrenocorticotropic hormone (ACTH)-induced hypertension in the rat is characterized by nitric oxide deficiency. Tetrahydrobiopterin (BH4) is an essential cofactor for the enzyme nitric oxide synthase and glucocorticoids have been reported to reduce cytokine-induced BH4 production. Accordingly we hypothesized that ACTH-induced hypertension would be reversed by BH4 supplementation. Male Sprague-Dawley rats (n = 33) were treated with BH4 in vehicle (10 mg/kg/day i.p.) or vehicle alone (5 mg/kg/day...[Show more]
|Collections||ANU Research Publications|
|Source:||Clinical and Experimental Hypertension|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.