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Spontaneous B cell hyperactivity in autoimmune-prone MRL mice

Nijnik, Anastasia; Ferry, Helen; Lewis, Graham; Rapsomaniki, Eleni; Leung, Janson C H; Daser, Angelika; Lambe, Teresa; Goodnow, Christopher; Cornall, Richard J

Description

The MRL-lpr/lpr mouse strain is a commonly used model of the human autoimmune disease systemic lupus erythematosus (SLE). Although much is known about the contribution of the lpr Fas mutation to B cell tolerance breakdown, the role of the genetic background of the MRL strain itself is less well explored. In this study, we use the MD4 anti-hen egg lysozyme Ig (IgHEL) transgenic system to explore B cell function in MRL+/+ and non-autoimmune mice. We demonstrate that MRL IgHEL B cells show...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/80892
Source: International Immunology
DOI: 10.1093/intimm/dxl047

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