The modal distribution of protein isoelectric points reflects amino acid properties rather than sequence evolution
Two-dimensional gel electrophoresis, a routine application in proteomics, separates proteins according to their molecular mass (Mr) and isoelectric point (p/). As the genomic sequences for more and more organisms are determined, the Mr and p/ of all their proteins can be estimated computationally. The examination of several of these theoretical proteome plots has revealed a multimodal p/ distribution, however, no conclusive explanation for this unusual distribution has so far been presented. We...[Show more]
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