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Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1

Qiao, Kangjian; Chooi, Yit-Heng; Tang, Yi

Description

Cytochalasins are a group of fungal secondary metabolites with diverse structures and bioactivities, including cytochalasin E produced by Aspergillus clavatus, which is a potent anti-angiogenic agent. Here, we report the identification and characterization of the cytochalasin gene cluster from A. clavatus NRRL 1. As a producer of cytochalasin E and K, the genome of A. clavatus was analyzed and the ~30 kb ccs gene cluster was identified based on the presence of a polyketide synthase-nonribosomal...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/80750
Source: Metabolic Engineering
DOI: 10.1016/j.ymben.2011.09.008

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