Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in streptomyces rimosus
Tetracyclines are clinically important aromatic polyketides whose biosynthesis is catalysed by bacterial type 2 polyketide synthases (PKSs). Tetracyclines are biosynthesized starting with an amide-containing malonamate starter unit and the resulting C-2 carboxyamide is critical for the antibiotic activities. In this work, we genetically verified that an amidotransferase, OxyD, and a thiolase, OxyP, are involved in the biosynthesis and incorporation of the starter unit. First, two mutations,...[Show more]
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