Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in streptomyces rimosus
-
Altmetric Citations
Wang, Peng; Gao, Xue; Chooi, Yit-Heng; Deng, Zixin; Tang, Yi
Description
Tetracyclines are clinically important aromatic polyketides whose biosynthesis is catalysed by bacterial type 2 polyketide synthases (PKSs). Tetracyclines are biosynthesized starting with an amide-containing malonamate starter unit and the resulting C-2 carboxyamide is critical for the antibiotic activities. In this work, we genetically verified that an amidotransferase, OxyD, and a thiolase, OxyP, are involved in the biosynthesis and incorporation of the starter unit. First, two mutations,...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/80739 |
Source: | Microbiology (UK) |
DOI: | 10.1099/mic.0.048439-0 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Wang_Genetic_characterization_of_2011.pdf | 265.84 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 19 May 2020/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator