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Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in streptomyces rimosus

Wang, Peng; Gao, Xue; Chooi, Yit-Heng; Deng, Zixin; Tang, Yi


Tetracyclines are clinically important aromatic polyketides whose biosynthesis is catalysed by bacterial type 2 polyketide synthases (PKSs). Tetracyclines are biosynthesized starting with an amide-containing malonamate starter unit and the resulting C-2 carboxyamide is critical for the antibiotic activities. In this work, we genetically verified that an amidotransferase, OxyD, and a thiolase, OxyP, are involved in the biosynthesis and incorporation of the starter unit. First, two mutations,...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Microbiology (UK)
DOI: 10.1099/mic.0.048439-0


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